Methods: The fNCITM and Notus NeuroCogsTM protocol was initially performed on a population of 60 normative reference volunteers (32 Female, 28 Male) between the ages of 19-57 years old to produce a normative atlas. Four patients with clinical complaints of cognitive impairment underwent fNCITM and Notus NeuroCogsTM imaging and were compared to the normative atlas.
Results: Structural imaging of Patient A-D alone could not confirm the diagnosis of MND. Patient A demonstrated severe cognitive deficits in 16 of 57 regions of interest (ROI), patient B in 26 of 57 ROI, patient C in 20 of 57 ROI, and patient D in 14 of 57 ROI. These results correspond with Moderate, Severe, Severe, and Moderate neurovascular uncoupling, respectively.
Conclusions: This report outlines the novel use of fMRI in the assessment of MND and demonstrates its effective use in four patients. Specifically, we show the protocol’s possible use as a clinical tool in characterizing the severity of cognitive impairment and early detection of cognitive impairment in patients at risk for MND.
Published on: August 17, 2017
Citation: Epps CT, Tucker BJ, Fong AK, Allen MD. 2017. Functional NeuroCognitive ImagingTM and Notus NeuroCogsTM: A Novel Use of MRI in the Assessment of Cognitive Function in Major Neurocognitive Disorder. J Neuroimaging Psychiatry Neurol 2(1): 11-19.